Inventa et Scientia
格物致知
Lee J.-Y. Laboratory: Membrane Lipid Transport
Kadambari Vijay Sai and Jyh-Yeuan Lee.
Crossing the membrane - what does it take to flip a phospholipid? Structural and biochemical advances on P4-ATPase flippases. Journal of Biological Chemistry (JBC). 300(10): 107738, DOI: 10.1016/j.jbc.2024.107738 (2024).
Sarah Wazir, Danny Farhat, Mahalashmi Srinivasan, and Jyh-Yeuan Lee.
ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography. Journal of Visualized Experiments (JoVE). 198, e65828, DOI: 10.3791/65828 (2023).
Fatemeh Rezaei, Danny Farhat, Gonca Gursu, Sabrina Samnani, and Jyh-Yeuan Lee.
Snapshots of ABCG1 and ABCG5/G8: A Sterol’s Journey to Cross the Cellular Membranes. International Journal of Molecular Sciences. 24(1), 484, DOI: 10.3390/ijms24010484 (2023), epub 2022 December 28
Danny Farhat, Fatemeh Rezaei, and Jyh-Yeuan Lee.
Data on structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8. Data in Brief. 45, 108754, DOI: 10.1016/j.dib.2022.108754 (2022), epub 2022 November 17
Danny Farhat, Fatemeh Rezaei, Milica Ristovski, Yidai Yang, Albert Stancescu, Lucia Dzimkova, Sabrina Samnani, Jean-Francois Couture, and Jyh-Yeuan Lee.
Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8. Journal of Molecular Biology. 434(20), 167795, DOI: 10.1016/j.jmb.2022.167795 (2022), epub 2022 August 18 (bioRxiv DOI: 10.1101/2022.05.18.492512)
Solmaz Maleki Dizaj, Sara Salatin, Khadijeh Khezri, Jyh-Yeuan Lee, and Farzaneh Lotfipour.
Targeting Multidrug Resistance With Antimicrobial Peptide-Decorated Nanoparticles and Polymers. Frontiers in Microbiology, 13, 831655, DOI: 10.3389/fmicb.2022.831655 (2022), epub 2022 March 31
Miliça Ristovski, Danny Farhat, Shelly Ellaine M. Bancud, and Jyh-Yeuan Lee.
Lipid transporters beam signals from cell membranes. Membranes, 11(8), 562, DOI: 10.3390/membranes11080562 (2021), epub 2021 July 26 (Preprints DOI: 10.20944/preprints202107.0244.v1)
Bala M. Xavier, Aiman A. Zein, Angelica Venes, Junmei Wang, and Jyh-Yeuan Lee.
Transmembrane polar relay drives the allosteric regulation for ABCG5/G8 sterol transporter. International Journal of Molecular Sciences, 21(22), 8747, DOI: 10.3390/ijms21228747 (2020), epub 2020 November 19th (bioRxiv DOI: 10.1101/2020.10.06.327825)
Narakorn Khunweeraphong, James Mitchell‐White, Dániel Szöllősi, Toka Hussein, Karl Kuchler, Ian D. Kerr, Thomas Stockner, and Jyh‐Yeuan Lee.
Picky ABCG5/G8 and promiscuous ABCG2 ‐ a tale of fatty diets and drug toxicity. FEBS Letters, 594(23): 4035-4058, DOI: 10.1002/1873-3468.13938 (2020), epub 2020 September 26th.
Aiman A. Zein, Rupinder Kaur, Toka O.K. Hussein, Gregory A. Graf, and Jyh-Yeuan Lee.
ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion. Biochemical Society Transactions (London), 47(5): 1259-1268, DOI: 10.1042/BST20190130 (2019), epub 2019 October 18th.
Bala M. Xavier, William Jennings, Aiman Zein, Junmei Wang, and Jyh-Yeuan Lee.
Structural snapshot of the cholesterol-transport ATP-binding cassette proteins. Biochemistry and Cell Biology, 97(3): 224-233, DOI: 10.1139/bcb-2018-0151 (2018), epub 2018 July 30th.
Jyh-Yeuan Lee and Daniel M. Rosenbaum.
Transporters Revealed. Cell, 168(6): 951-953, DOI: 10.1016/j.cell.2017.02.033 (2017).
Jyh-Yeuan Lee, Lisa N. Kinch, Dominika M. Borek, Jin Wang, Junmei Wang, Ina L. Urbatsch, Xiao-Song Xie, Nikolai V. Grishin, Jonathan C. Cohen, Zbyszek Otwinowski, Helen H. Hobbs, and Daniel M. Rosenbaum.
Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8. Nature, 533(7604): 561-564, DOI: 10.1038/nature17666 (2016).