Inventa et Scientia
格物致知
Lee J.-Y. Laboratoire: Membrane Lipid Transport
Transport membranaire des phospholipides :
Kadambari Vijay Sai, Sai Anvithaa Sundar Rajan, and Jyh-Yeuan Lee.
Sequence Analysis of P4-ATPases Reveals the Structural Determinants for the Stable Monomeric P4B-ATPase Phospholipid Transporters. bioRxiv MS ID#: BIORXIV/2025/662597 (2025).
Kadambari Vijay Sai and Jyh-Yeuan Lee.
Crossing the membrane - what does it take to flip a phospholipid? Structural and biochemical advances on P4-ATPase flippases. Journal of Biological Chemistry (JBC). 300(10): 107738, DOI: 10.1016/j.jbc.2024.107738 (2024).
Métabolisme du cholestérol et homéostasie des protéines:
Hong Y. Choi, Isabelle Ruel, Shiwon Choi, Iulia Iatan, Senna Choi, Jyh-Yeuan Lee and Jacques Genest.
Low-dose docetaxel is effective in reducing atherogenic lipids and atherosclerosis. International Journal of Molecular Sciences. 26, 1484, DOI: 10.3390/ijms26041484 (2025), epub 2025 February 11
Sarah Wazir, Danny Farhat, Mahalashmi Srinivasan, and Jyh-Yeuan Lee.
ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography. Journal of Visualized Experiments (JoVE). 198, e65828, DOI: 10.3791/65828 (2023).
Fatemeh Rezaei, Danny Farhat, Gonca Gursu, Sabrina Samnani, and Jyh-Yeuan Lee.
Snapshots of ABCG1 and ABCG5/G8: A Sterol’s Journey to Cross the Cellular Membranes. International Journal of Molecular Sciences. 24(1), 484, DOI: 10.3390/ijms24010484 (2023), epub 2022 December 28
Danny Farhat, Fatemeh Rezaei, and Jyh-Yeuan Lee.
Data on structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8. Data in Brief. 45, 108754, DOI: 10.1016/j.dib.2022.108754 (2022), epub 2022 November 17
Danny Farhat, Fatemeh Rezaei, Milica Ristovski, Yidai Yang, Albert Stancescu, Lucia Dzimkova, Sabrina Samnani, Jean-Francois Couture, and Jyh-Yeuan Lee.
Structural analysis of cholesterol binding and sterol selectivity by ABCG5/G8. Journal of Molecular Biology. 434(20), 167795, DOI: 10.1016/j.jmb.2022.167795 (2022), epub 2022 August 18 (bioRxiv DOI: 10.1101/2022.05.18.492512)
Miliça Ristovski, Danny Farhat, Shelly Ellaine M. Bancud, and Jyh-Yeuan Lee.
Lipid transporters beam signals from cell membranes. Membranes, 11(8), 562, DOI: 10.3390/membranes11080562 (2021), epub 2021 July 26 (Preprints DOI: 10.20944/preprints202107.0244.v1)
Bala M. Xavier, Aiman A. Zein, Angelica Venes, Junmei Wang, and Jyh-Yeuan Lee.
Transmembrane polar relay drives the allosteric regulation for ABCG5/G8 sterol transporter. International Journal of Molecular Sciences, 21(22), 8747, DOI: 10.3390/ijms21228747 (2020), epub 2020 November 19th (bioRxiv DOI: 10.1101/2020.10.06.327825)
Narakorn Khunweeraphong, James Mitchell‐White, Dániel Szöllősi, Toka Hussein, Karl Kuchler, Ian D. Kerr, Thomas Stockner, and Jyh‐Yeuan Lee.
Picky ABCG5/G8 and promiscuous ABCG2 ‐ a tale of fatty diets and drug toxicity. FEBS Letters, 594(23): 4035-4058, DOI: 10.1002/1873-3468.13938 (2020), epub 2020 September 26th.
Aiman A. Zein, Rupinder Kaur, Toka O.K. Hussein, Gregory A. Graf, and Jyh-Yeuan Lee.
ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion. Biochemical Society Transactions (London), 47(5): 1259-1268, DOI: 10.1042/BST20190130 (2019), epub 2019 October 18th.
Bala M. Xavier, William Jennings, Aiman Zein, Junmei Wang, and Jyh-Yeuan Lee.
Structural snapshot of the cholesterol-transport ATP-binding cassette proteins. Biochemistry and Cell Biology, 97(3): 224-233, DOI: 10.1139/bcb-2018-0151 (2018), epub 2018 July 30th.
Jyh-Yeuan Lee, Lisa N. Kinch, Dominika M. Borek, Jin Wang, Junmei Wang, Ina L. Urbatsch, Xiao-Song Xie, Nikolai V. Grishin, Jonathan C. Cohen, Zbyszek Otwinowski, Helen H. Hobbs, and Daniel M. Rosenbaum.
Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8. Nature, 533(7604): 561-564, DOI: 10.1038/nature17666 (2016).
Brandy J.H. Johnson, Jyh-Yeuan Lee, Amanda Pickert, and Ina L. Urbatsch.
Bile Acids Stimulated ATP Hydrolysis in the Purified Cholesterol Transporter ABCG5/G8. Biochemistry, 49(16): 3403-3411, DOI: 10.1021/bi902064g (2010).
Résistance multimédicamenteuse:
Solmaz Maleki Dizaj, Sara Salatin, Khadijeh Khezri, Jyh-Yeuan Lee, and Farzaneh Lotfipour.
Targeting Multidrug Resistance With Antimicrobial Peptide-Decorated Nanoparticles and Polymers. Frontiers in Microbiology, 13, 831655, DOI: 10.3389/fmicb.2022.831655 (2022), epub 2022 March 31
Jyh-Yeuan Lee and Daniel M. Rosenbaum.
Transporters Revealed. Cell, 168(6): 951-953, DOI: 10.1016/j.cell.2017.02.033 (2017).
Jyh-Yeuan Lee, Ina L. Urbatsch, Alan E. Senior, and Stephan Wilkens.
Nucleotide-induced Structural Changes in P-glycoprotein Observed by Electron Microscopy. Journal of Biological Chemistry, 283(9): 5769-79, DOI: 10.1074/jbc.M707028200 (2008)
Maja Chloupková, Amanda Pickert, Jyh-Yeuan Lee, Shiloe Souza, Yenphuong T. Trinh, Sara M. Connelly, Mark E. Dumont, Michael Dean, and Ina L. Urbatsch.
Expression of 25 Human ABC Transporters in the yeast Pichia pastoris and Characterization of the Purified ABCC3 ATPase Activity. Biochemistry, 46(27): 7992-8003, DOI: 10.1021/bi700020m (2007).
Jyh-Yeuan Lee, Ina L. Urbatsch, Alan E. Senior, and Stephan Wilkens.
Projection Structure of P-glycoprotein by Electron Microscopy: Evidence for a Closed Conformation of the Nucleotide-Binding Domains. Journal of Biological Chemistry, 277(42): 40125-31, DOI: 10.1074/jbc.M206871200 (2002).